Chiu Lab Publications

2026

Aydin D, Chien CT, Kreiter J, Nava AR, Portasikova JM, Fojtik L, Sobecks BL, Mosquera C, Man P, Dror RO, Chiu W, Maduke M. Molecular mechanism of exchange coupling in CLC chloride/proton antiporters. Nature communications. 2026;. Epub 2026/01/08. doi: 10.1038/s41467-025-68098-1. PubMed PMID: 41507156.

2025

Kretsch RC, Li S, Pintilie G, Palo MZ, Case DA, Das R, Zhang K, Chiu W. Complex water networks visualized by cryogenic electron microscopy of RNA. Nature. 2025;642(8066):250-9. Epub 2025/03/12. doi: 10.1038/s41586-025-08855-w. PubMed PMID: 40068818; PMCID: PMC12137144.

Varanese L, Xu L, Peters CE, Pintilie G, Roberts DS, Raj S, Liu M, Ooi YS, Diep J, Qiao W, Richards CM, Callaway J, Bertozzi CR, Jabs S, de Vries E, van Kuppeveld FJM, Nagamine CM, Chiu W, Carette JE. MFSD6 is an entry receptor for enterovirus D68. Nature. 2025. Epub 2025/03/26. doi: 10.1038/s41586-025-08908-0. PubMed PMID: 40132641.

Chien CT, Maduke M, Chiu W. Single-particle cryogenic electron microscopy structure determination for membrane proteins. Curr Opin Struct Biol. 2025;92:103047. Epub 2025/04/15. doi: 10.1016/j.sbi.2025.103047. PubMed PMID: 40228430.

Kretsch RC, Wu Y, Shabalina SA, Lee H, Nye G, Koonin EV, Gao A, Chiu W, Das R. Naturally ornate RNA-only complexes revealed by cryo-EM. Nature. 2025;643(8073):1135-42. Epub 2025/05/07. doi: 10.1038/s41586-025-09073-0. PubMed PMID: 40328315; PMCID: PMC12286853.

Pintilie G, Shao C, Wang Z, Hudson BP, Flatt JW, Schmid MF, Morris KL, Burley SK, Chiu W. Q-score as a reliability measure for protein, nucleic acid and small-molecule atomic coordinate models derived from 3DEM maps. Acta Crystallogr D Struct Biol. 2025;81(Pt 8):410-22. Epub 2025/07/14. doi: 10.1107/S2059798325005923. PubMed PMID: 40654171; PMCID: PMC12315582.

Zhao Y, Schmid MF, Chiu W. Visualizing dynamic tubulin folding in chaperonin TRiC from nonnative nucleus to final native state. Nat Commun. 2025;16(1):7878. Epub 2025/08/26. doi: 10.1038/s41467-025-63016-x. PubMed PMID: 40849413; PMCID: PMC12375087.

Wu GH, Hou C, Thron A, Patel HR, Spillane L, Gupte SR, Yeung-Levy S, Gulati S, Booth C, Liao YJ, Chiu W. Cryogenic electron tomography and elemental analysis of mitochondrial granules in human retinal ganglion cells. Structure. 2025. Epub 2025/08/06. doi: 10.1016/j.str.2025.07.010. PubMed PMID: 40763734.

Zhang, Z, Lee, JKL, Li, Y, Zhou, W., Wu, GH, Lyu, H, Wan, J., Chen, H, Huang, W, Ye, Y, Cui, Y, Schmid, MF, Chiu, W, Cui, Y. Resolving Three-Dimensional Nanoscale Heterogeneities in Lithium Metal Batteries with Cryogenic Electron Tomography. Matter 2025 in press.

Burgess J, Nirschl JJ, Bravo-Sanchez L, Lozano A, Gupte SR, Galaz-Montoya JG, Zhang Y, Su Y, Bhowmik D, Coman Z, Hasan SM, Johannesson A, Leineweber WD, Nair MG, Yarlagadda R, Zuraski C, Chiu W, Cohen S, Hansen JN, Leonetti MD, Liu C, Lundberg E, Yeung-Levy S. MicroVQA: A Multimodal Reasoning Benchmark for Microscopy-Based Scientific Research. ArXiv. 2025. Epub 2025/04/01. PubMed PMID: 40166749; PMCID: PMC11957224.

Kretsch RC, Albrecht R, Andersen ES, Chen HA, Chiu W, Das R, Gezelle JG, Hartmann MD, Hobartner C, Hu Y, Jadhav S, Johnson PE, Jones CP, Koirala D, Kristoffersen EL, Largy E, Lewicka A, Mackereth CD, Marcia M, Nigro M, Ojha M, Piccirilli JA, Rice PA, Shin H, Steckelberg AL, Su Z, Srivastava Y, Wang L, Wu Y, Xie J, Zwergius NH, Moult J, Kryshtafovych A. Functional Relevance of CASP16 Nucleic Acid Predictions as Evaluated by Structure Providers. Proteins. 2025. Epub 2025/09/04. doi: 10.1002/prot.70043. PubMed PMID: 40905273; PMCID: PMC12412911.

Kretsch RC, Posani E, Baulin EF, Bujnicki JM, Bussi G, Cheatham TE, 3rd, Chen SJ, Elofsson A, Farsani MA, Fisher ON, Gromiha MM, Gupta A, Hamada M, Harini K, Hu G, Huang D, Iwakiri J, Jain A, Kagaya Y, Kihara D, Kmiecik S, Krishnan SR, Kurisaki I, Languin-Cattoen O, Li J, Li S, Malekzadeh K, Nakamura T, Ni W, Nithin C, Palo MZ, Park JH, Pilla SP, Poblete S, Pucci F, Punuru P, Saha A, Sato K, Srivastava A, Terashi G, Tugolukova E, Verburgt J, Wuyun Q, Zerze GH, Zhang K, Zhang S, Zheng W, Zhou Y, Chiu W, Case DA, Das R. Blind Prediction of Complex Water and Ion Ensembles Around RNA in CASP16. Proteins. 2025. Epub 2025/11/08. doi: 10.1002/prot.70079. PubMed PMID: 41204761.

Cui, Y., Zhang, Z., Sinclair, R., Chiu, W. Cui, Y. Cryogenic electron microscopy and tomography for beam-sensitive materials. Nat Rev Phys (2025). https://doi-org.stanford.idm.oclc.org/10.1038/s42254-025-00896-4

2024

Chen M, Schmid MF, Chiu W. Improving resolution and resolvability of single-particle cryoEM structures using Gaussian mixture models. Nat Methods. 2024;21(1):37-40. Epub 2023/11/17. doi: 10.1038/s41592-023-02082-9. PubMed PMID: 37973972; PMCID: PMC10860619.

Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie GD, Bois JD, Dror RO, Chiu W, Maduke M. CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. Elife. 2024;12. Epub 2024/02/12. doi: 10.7554/eLife.90648. PubMed PMID: 38345841.

Kretsch RC, Xu L, Zheludev IN, Zhou X, Huang R, Nye G, Li S, Zhang K, Chiu W, Das R. Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc Natl Acad Sci U S A. 2024;121(10):e2320493121. Epub 2024/03/01. doi: 10.1073/pnas.2320493121. PubMed PMID: 38427602.

Chmielewski D, Su GC, Kaelber JT, Pintilie GD, Chen M, Jin J, Auguste AJ, Chiu W. Cryogenic electron microscopy and tomography reveal imperfect icosahedral symmetry in alphaviruses. PNAS Nexus. 2024;3(3):pgae102. Epub 2024/03/25. doi: 10.1093/pnasnexus/pgae102. PubMed PMID: 38525304; PMCID: PMC10959069.

Lawson CL, Kryshtafovych A, Pintilie GD, Burley SK, Cerny J, Chen VB, Emsley P, Gobbi A, Joachimiak A, Noreng S, Prisant MG, Read RJ, Richardson JS, Rohou AL, Schneider B, Sellers BD, Shao C, Sourial E, Williams CI, Williams CJ, Yang Y, Abbaraju V, Afonine PV, Baker ML, Bond PS, Blundell TL, Burnley T, Campbell A, Cao R, Cheng J, Chojnowski G, Cowtan KD, DiMaio F, Esmaeeli R, Giri N, Grubmuller H, Hoh SW, Hou J, Hryc CF, Hunte C, Igaev M, Joseph AP, Kao WC, Kihara D, Kumar D, Lang L, Lin S, Maddhuri Venkata Subramaniya SR, Mittal S, Mondal A, Moriarty NW, Muenks A, Murshudov GN, Nicholls RA, Olek M, Palmer CM, Perez A, Pohjolainen E, Pothula KR, Rowley CN, Sarkar D, Schafer LU, Schlicksup CJ, Schroder GF, Shekhar M, Si D, Singharoy A, Sobolev OV, Terashi G, Vaiana AC, Vedithi SC, Verburgt J, Wang X, Warshamanage R, Winn MD, Weyand S, Yamashita K, Zhao M, Schmid MF, Berman HM, Chiu W. Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge. Nat Methods. 2024;21(7):1340-8. Epub 2024/06/26. doi: 10.1038/s41592-024-02321-7. PubMed PMID: 38918604.

Sun SY, Segev-Zarko La, Pintilie GD, Kim CY, Staggers SR, Schmid MF, Egan ES, Chiu W, Boothroyd JC. Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum. mBio. 2024;15(4):e0286423. Epub 2024/03/08. doi: 10.1128/mbio.02864-23. PubMed PMID: 38456679; PMCID: PMC11005440.

Van Veen D, Galaz-Montoya JG, Shen L, Baldwin P, Chaudhari AS, Lyumkis D, Schmid MF, Chiu W, Pauly J. Missing Wedge Completion via Unsupervised Learning with Coordinate Networks. Int J Mol Sci. 2024;25(10). Epub 2024/05/25. doi: 10.3390/ijms25105473. PubMed PMID: 38791508; PMCID: PMC11121946.

Li Y, Liu Y, Zhang Z, Zhou W, Xu J, Ye Y, Peng Y, Xiao X, Chiu W, Sinclair R, Li Y, Cui Y. Electrified Operando-Freezing of Electrocatalytic CO(2) Reduction Cells for Cryogenic Electron Microscopy. Nano Lett. 2024;24(34):10409-17. Epub 2024/08/19. doi: 10.1021/acs.nanolett.3c03000. PubMed PMID: 3915801

Chien CT, Puhl H, Vogel SS, Molloy JE, Chiu W, Khan S. Hub stability in the calcium calmodulin-dependent protein kinase II. Commun Biol. 2024;7(1):766. Epub 2024/06/26. doi: 10.1038/s42003-024-06423-y. PubMed PMID: 38918547; PMCID: PMC11199487.

Findinier J, Joubert LM, Fakhimi N, Schmid MF, Malkovskiy AV, Chiu W, Burlacot A, Grossman AR. Dramatic changes in mitochondrial subcellular location and morphology accompany activation of the CO2 concentrating mechanism. Proc Natl Acad Sci U S A. 2024;121(43):e2407548121. Epub 2024/10/15. doi: 10.1073/pnas.2407548121. PubMed PMID: 39405346; PMCID: PMC11513932.

Zhao Y, Schmid MF, Chiu W. Cost-benefit analysis of cryogenic electron tomography subtomogram averaging of chaperonin MmCpn at near atomic resolution. Structure. 2025;33(2):372-80 e2. Epub 2024/12/08. doi: 10.1016/j.str.2024.11.008. PubMed PMID: 39644888; PMCID: PMC11805670.

Bu F, Adam Y, Adamiak RW, Antczak M, de Aquino BRH, Badepally NG, Batey RT, Baulin EF, Boinski P, Boniecki MJ, Bujnicki JM, Carpenter KA, Chacon J, Chen SJ, Chiu W, Cordero P, Das NK, Das R, Dawson WK, DiMaio F, Ding F, Dock-Bregeon AC, Dokholyan NV, Dror RO, Dunin-Horkawicz S, Eismann S, Ennifar E, Esmaeeli R, Farsani MA, Ferre-D'Amare AR, Geniesse C, Ghanim GE, Guzman HV, Hood IV, Huang L, Jain DS, Jaryani F, Jin L, Joshi A, Karelina M, Kieft JS, Kladwang W, Kmiecik S, Koirala D, Kollmann M, Kretsch RC, Kurcinski M, Li J, Li S, Magnus M, Masquida B, Moafinejad SN, Mondal A, Mukherjee S, Nguyen THD, Nikolaev G, Nithin C, Nye G, Pandaranadar Jeyeram IPN, Perez A, Pham P, Piccirilli JA, Pilla SP, Pluta R, Poblete S, Ponce-Salvatierra A, Popenda M, Popenda L, Pucci F, Rangan R, Ray A, Ren A, Sarzynska J, Sha CM, Stefaniak F, Su Z, Suddala KC, Szachniuk M, Townshend R, Trachman RJ, 3rd, Wang J, Wang W, Watkins A, Wirecki TK, Xiao Y, Xiong P, Xiong Y, Yang J, Yesselman JD, Zhang J, Zhang Y, Zhang Z, Zhou Y, Zok T, Zhang D, Zhang S, Zyla A, Westhof E, Miao Z. RNA-Puzzles Round V: blind predictions of 23 RNA structures. Nat Methods. 2025;22(2):399-411. Epub 2024/12/03. doi: 10.1038/s41592-024-02543-9. PubMed PMID: 39623050; PMCID: PMC11810798.

2023

Wu GH, Smith-Geater C, Galaz-Montoya JG, Gu Y, Gupte SR, Aviner R, Mitchell PG, Hsu J, Miramontes R, Wang KQ, Geller NR, Hou C, Danita C, Joubert LM, Schmid MF, Yeung S, Frydman J, Mobley W, Wu C, Thompson LM, Chiu W. CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons. Nat Commun. 2023;14(1):692. Epub 2023/02/09. doi: 10.1038/s41467-023-36096-w. PubMed PMID: 36754966; PMCID: PMC9908936.

Li S, Zhang K, Chiu W. Near-Atomic Resolution Cryo-EM Image Reconstruction of RNA. Methods Mol Biol. 2023; 2568:179-92. Epub 2022/10/14. doi: 10.1007/978-1-0716-2687-0_12. PubMed PMID: 36227569.

Parsons MF, Allan MF, Li S, Shepherd TR, Ratanalert S, Zhang K, Pullen KM, Chiu W, Rouskin S, Bathe M. 3D RNA-scaffolded wireframe origami. Nat Commun. 2023;14(1):382. Epub 2023/01/25. doi: 10.1038/s41467-023-36156-1. PubMed PMID: 36693871; PMCID: PMC9872083.

Kretsch RC, Andersen ES, Bujnicki JM, Chiu W, Das R, Luo B, Masquida B, McRae EKS, Schroeder GM, Su Z, Wedekind JE, Xu L, Zhang K, Zheludev IN, Moult J, Kryshtafovych A. RNA target highlights in CASP15: Evaluation of predicted models by structure providers. Proteins. 2023. Epub 2023/07/19. doi: 10.1002/prot.26550. PubMed PMID: 37466021.

Dudek NK, Galaz-Montoya JG, Shi H, Mayer M, Danita C, Celis AI, Viehboeck T, Wu GH, Behr B, Bulgheresi S, Huang KC, Chiu W, Relman DA. Previously uncharacterized rectangular bacterial structures in the dolphin mouth. Nat Commun. 2023;14(1):2098. Epub 2023/04/14. doi: 10.1038/s41467-023-37638-y. PubMed PMID: 37055390; PMCID: PMC10102025.

Chmielewski D, Wilson EA, Pintilie G, Zhao P, Chen M, Schmid MF, Simmons G, Wells L, Jin J, Singharoy A, Chiu W. Structural insights into the modulation of coronavirus spike tilting and infectivity by hinge glycans. Nat Commun. 2023;14(1):7175. Epub 2023/11/08. doi: 10.1038/s41467-023-42836-9. PubMed PMID: 37935678; PMCID: PMC10630519.

Walsh MA, Nannenga BL, Gonen T, Sexton PM, Wootten D, Chiu W, Sun F, Carragher B, Potter CS, Agard D, Burley SK. The next decade in structural biology. Structure. 2023;31(11):1284-8. Epub 2023/11/06. doi: 10.1016/j.str.2023.10.002. PubMed PMID: 37922863.

Zhou M, Vollmer B, Machala E, Chen M, Grunewald K, Arvin AM, Chiu W, Oliver SL. Targeted mutagenesis of the herpesvirus fusogen central helix captures transition states. Nat Commun. 2023;14(1):7958. Epub 2023/12/03. doi: 10.1038/s41467-023-43011-w. PubMed PMID: 38042814; PMCID: PMC10693595.

2022

Zhou W, Bammes B, Mitchell PG, Betz K, Chiu W. Electron crystallography of chiral and non-chiral small molecules. Ultramicroscopy. 2022;232:113417. Epub 2021/10/26. doi: 10.1016/j.ultramic.2021.113417. PubMed PMID: 34695647; PMCID: PMC8794741.

Zhou W, Bammes B, Mitchell PG, Betz K, Chiu W. Corrigendum to "Electron crystallography of chiral and non-chiral small molecules" [Ultramicroscopy 232 (2022) 113417]. Ultramicroscopy. 2022:113474. Epub 2022/01/30. doi: 10.1016/j.ultramic.2022.113474. PubMed PMID: 35090780.

Zhang, Z., Y. Li, R. Xu, W. Zhou, Y. Li, S. T. Oyakhire, Y. Wu, J. Xu, H. Wang, Z. Yu, D. T. Boyle, W. Huang, Y. Ye, H. Chen, J. Wan, Z. Bao, W. Chiu and Y. Cui (2022). Capturing the swelling of solid-electrolyte interphase in lithium metal batteries. Science 375(6576): 66-70.

Sun SY, Segev-Zarko LA, Chen M, Pintilie GD, Schmid MF, Ludtke SJ, Boothroyd JC, Chiu W. Cryo-ET of Toxoplasma parasites gives subnanometer insight into tubulin-based structures. Proc Natl Acad Sci U S A. 2022;119(6). doi: 10.1073/pnas.2111661119. PubMed PMID: 35121661; PMCID: PMC8832990.

Zhang K, Horikoshi N, Li S, Powers AS, Hameedi MA, Pintilie GD, Chae HD, Khan YA, Suomivuori CM, Dror RO, Sakamoto KM, Chiu W, Wakatsuki S. Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia. ACS Cent Sci. 2022;8(2):214-22. doi: 10.1021/acscentsci.1c01090. PubMed PMID: 35233453; PMCID: PMC8875425.

Wang Y, Binning JM, Pintilie GD, Chiu W, Amarasinghe GK, Leung DW, Su Z. Cryo-EM analysis of Ebola virus nucleocapsid-like assembly. STAR Protoc. 2022;3(1):101030. Epub 2022/01/04. doi: 10.1016/j.xpro.2021.101030. PubMed PMID: 34977676; PMCID: PMC8689349.

Danita C, Chiu W, Galaz-Montoya JG. Efficient manual annotation of cryogenic electron tomograms using IMOD. STAR Protoc. 2022;3(3):101658. Epub 2022/09/14. doi: 10.1016/j.xpro.2022.101658. PubMed PMID: 36097385; PMCID: PMC9463458.

Tierney WM, Vicino IA, Sun SY, Chiu W, Engel EA, Taylor MP, Hogue IB. Methods and Applications of Campenot Trichamber Neuronal Cultures for the Study of Neuroinvasive Viruses. Methods Mol Biol. 2022;2431:181-206. Epub 2022/04/13. doi: 10.1007/978-1-0716-1990-2_9. PubMed PMID: 35412277; PMCID: PMC10427112.

Chmielewski D, Schmid MF, Simmons G, Jin J, Chiu W. Chikungunya virus assembly and budding visualized in situ using cryogenic electron tomography. Nat Microbiol. 2022;7(8):1270-9. Epub 2022/07/01. doi: 10.1038/s41564-022-01164-2. PubMed PMID: 35773421; PMCID: PMC9930444.

Li S, Palo MZ, Pintilie G, Zhang X, Su Z, Kappel K, Chiu W, Zhang K, Das R. Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM. Proc Natl Acad Sci U S A. 2022;119(37):e2209146119. Epub 2022/09/07. doi: 10.1073/pnas.2209146119. PubMed PMID: 36067294; PMCID: PMC9477386.

Powell AE, Xu D, Roth GA, Zhang K, Chiu W, Appel EA, Kim PS. Multimerization of Ebola GPDeltamucin on protein nanoparticle vaccines has minimal effect on elicitation of neutralizing antibodies. Front Immunol. 2022;13:942897. Epub 2022/09/13. doi: 10.3389/fimmu.2022.942897. PubMed PMID: 36091016; PMCID: PMC9449635.

Burley SK, Berman HM, Chiu W, Dai W, Flatt JW, Hudson BP, Kaelber JT, Khare SD, Kulczyk AW, Lawson CL, Pintilie GD, Sali A, Vallat B, Westbrook JD, Young JY, Zardecki C. Electron microscopy holdings of the Protein Data Bank: the impact of the resolution revolution, new validation tools, and implications for the future. Biophys Rev. 2022:1-21. Epub 2022/12/08. doi: 10.1007/s12551-022-01013-w. PubMed PMID: 36474933; PMCID: PMC9715422.

Gestaut D, Zhao Y, Park J, Ma B, Leitner A, Collier M, Pintilie G, Roh SH, Chiu W, Frydman J. Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT. Cell. 2022;185(25):4770-87 e20. Epub 2022/12/10. doi: 10.1016/j.cell.2022.11.014. PubMed PMID: 36493755; PMCID: PMC9735246.

Wang X, Li S, Jun H, John T, Zhang K, Fowler H, Doye JPK, Chiu W, Bathe M. Planar 2D wireframe DNA origami. Sci Adv. 2022;8(20):eabn0039. Epub 2022/05/21. doi: 10.1126/sciadv.abn0039. PubMed PMID: 35594345; PMCID: PMC9122324.

Dahlberg PD, Perez D, Hecksel CW, Chiu W, Moerner WE. Metallic support films reduce optical heating in cryogenic correlative light and electron tomography. J Struct Biol. 2022;214(4):107901. Epub 2022/10/04. doi: 10.1016/j.jsb.2022.107901. PubMed PMID: 36191745; PMCID: PMC9729463.

Segev-Zarko LA, Dahlberg PD, Sun SY, Pelt DM, Kim CY, Egan ES, Sethian JA, Chiu W, Boothroyd JC. Cryo-electron tomography with mixed-scale dense neural networks reveals key steps in deployment of Toxoplasma invasion machinery. PNAS Nexus. 2022;1(4):pgac183. Epub 2022/11/05. doi: 10.1093/pnasnexus/pgac183. PubMed PMID: 36329726; PMCID: PMC9615128.

2021

Powell, AE, Zhang, K, Sanyal, M, Tang, S, Weidenbacher, PA, Li, S, Pham, TD, Pak, JE, Chiu, W, & Kim, PS (2021) A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice. ACS Cent Sci 7(1):183-199. PMCID7805605

Oliver, SL, Xing, Y, Chen, DH, Roh, SH, Pintilie, GD, Bushnell, DA, Sommer, MH, Yang, E, Carfi, A, Chiu, W, & Arvin, AM (2021) The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion. PLoS Pathog 17(1):e1008961. PMCID7817050.

Lee, HR, Liao, L, Xiao, W, Vailionis, A, Ricco, AJ, White, R, Nishi, Y, Chiu, W, Chu, S, & Cui, Y (2021) Three-Dimensional Analysis of Particle Distribution on Filter Layers inside N95 Respirators by Deep Learning. Nano Lett 21(1):651-657. PMCID7737533.

Chiu, W, Schmid, MF, Pintilie, GD, & Lawson, CL (2021) Evolution of standardization and dissemination of cryo-EM structures and data jointly by the community, PDB, and EMDB. J Biol Chem 296:100560. PMCID8050867.

Torabi, SF, Chen, YL, Zhang, K, Wang, J, DeGregorio, SJ, Vaidya, AT, Su, Z, Pabit, SA, Chiu, W, Pollack, L, & Steitz, JA (2021) Structural analyses of an RNA stability element interacting with poly(A). Proc Natl Acad Sci U S A 118(14). PMCID8040590.

Knowlton, JJ, Gestaut, D, Ma, B, Taylor, G, Seven, AB, Leitner, A, Wilson, GJ, Shanker, S, Yates, NA, Prasad, BVV, Aebersold, R, Chiu, W, Frydman, J, & Dermody, TS (2021) Structural and functional dissection of reovirus capsid folding and assembly by the prefoldin-TRiC/CCT chaperone network. Proc Natl Acad Sci U S A 118(11). PMCID7980406.

Lok SM, Chiu W. Preface. Prog Biophys Mol Biol. 2021;160:1. Epub 2020/12/04. doi: 10.1016/j.pbiomolbio.2020.11.004. PubMed PMID: 33271194.

Sarkans U, Chiu W, Collinson L, Darrow MC, Ellenberg J, Grunwald D, Heriche JK, Iudin A, Martins GG, Meehan T, Narayan K, Patwardhan A, Russell MRG, Saibil HR, Strambio-De-Castillia C, Swedlow JR, Tischer C, Uhlmann V, Verkade P, Barlow M, Bayraktar O, Birney E, Catavitello C, Cawthorne C, Wagner-Conrad S, Duke E, Paul-Gilloteaux P, Gustin E, Harkiolaki M, Kankaanpaa P, Lemberger T, McEntyre J, Moore J, Nicholls AW, Onami S, Parkinson H, Parsons M, Romanchikova M, Sofroniew N, Swoger J, Utz N, Voortman LM, Wong F, Zhang P, Kleywegt GJ, Brazma A. REMBI: Recommended Metadata for Biological Images-enabling reuse of microscopy data in biology. Nat Methods. 2021;18(12):1418-22. Epub 2021/05/23. doi: 10.1038/s41592-021-01166-8. PubMed PMID: 34021280; PMCID: PMC8606015.

Blanco Carcache PJ, Guo S, Li H, Zhang K, Xu C, Chiu W, Guo P. Regulation of reversible conformational change, size switching, and immunomodulation of RNA nanocubes. RNA. 2021;27(9):971-80. Epub 2021/07/02. doi: 10.1261/rna.078718.121. PubMed PMID: 34193550; PMCID: PMC8370748.

Galaz-Montoya, JG, Shahmoradian, SH, Shen, K, Frydman, J, & Chiu, W (2021) Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates. Commun Biol 4(1):849. PMCID8266869.

Su, Z, Zhang, K, Kappel, K, Li, S, Palo, MZ, Pintilie, GD, Rangan, R, Luo, B, Wei, Y, Das, R, & Chiu, W (2021) Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. Nature 10.1038/s41586-021-03803-w. PMCID8405103.

Zhao, Y, Schmid, MF, Frydman, J, & Chiu, W (2021) CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin. Nat Commun 12(1):4754. PMCID8346469.

Lawson CL, Kryshtafovych A, Adams PD, Afonine PV, Baker ML, Barad BA, Bond P, Burnley T, Cao R, Cheng J, Chojnowski G, Cowtan K, Dill KA, DiMaio F, Farrell DP, Fraser JS, Herzik MA, Jr., Hoh SW, Hou J, Hung LW, Igaev M, Joseph AP, Kihara D, Kumar D, Mittal S, Monastyrskyy B, Olek M, Palmer CM, Patwardhan A, Perez A, Pfab J, Pintilie GD, Richardson JS, Rosenthal PB, Sarkar D, Schafer LU, Schmid MF, Schroder GF, Shekhar M, Si D, Singharoy A, Terashi G, Terwilliger TC, Vaiana A, Wang L, Wang Z, Wankowicz SA, Williams CJ, Winn M, Wu T, Yu X, Zhang K, Berman HM, Chiu W (2021) Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge. Nature methods18(2):156-64. PMCID7864804.

Zhang K, Zheludev IN, Hagey RJ, Haslecker R, Hou YJ, Kretsch R, Pintilie GD, Rangan R, Kladwang W, Li S, Wu MT, Pham EA, Bernardin-Souibgui C, Baric RS, Sheahan TP, D'Souza V, Glenn JS, Chiu W, Das R. Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome. Nat Struct Mol Biol. 2021;28(9):747-54. Epub 2021/08/25. doi: 10.1038/s41594-021-00653-y. PubMed PMID: 34426697; PMCID: 8848339.

Zhang Z, Cui Y, Vila R, Li Y, Zhang W, Zhou W, Chiu W, Cui Y (2021) Cryogenic Electron Microscopy for Energy Materials. Accounts of chemical research 54(18):3505-17. Epub 2021/07/20. doi: 10.1021/acs.accounts.1c00183. PubMed PMID: 34278783.

Li H, Zhang K, Binzel DW, Shlyakhtenko LS, Lyubchenko YL, Chiu W, Guo P. RNA nanotechnology to build a dodecahedral genome of single-stranded RNA virus. RNA Biol. 2021;18(12):2390-400. Epub 2021/04/14. doi: 10.1080/15476286.2021.1915620. PubMed PMID: 33845711; PMCID: PMC8632126.

Jun H, Wang X, Parsons MF, Bricker WP, John T, Li S, Jackson S, Chiu W, Bathe M (2021) Rapid prototyping of arbitrary 2D and 3D wireframe DNA origami. Nucleic Acids Res 49(18):10265-74. PMCID8501967.

Alexander LT, Lepore R, Kryshtafovych A, Adamopoulos A, Alahuhta M, Arvin AM, Bomble YJ, Bottcher B, Breyton C, Chiarini V, Chinnam NB, Chiu W, Fidelis K, Grinter R, Gupta GD, Hartmann MD, Hayes CS, Heidebrecht T, Ilari A, Joachimiak A, Kim Y, Linares R, Lovering AL, Lunin VV, Lupas AN, Makbul C, Michalska K, Moult J, Mukherjee PK, Nutt WS, Oliver SL, Perrakis A, Stols L, Tainer JA, Topf M, Tsutakawa SE, Valdivia-Delgado M, Schwede T (2021) Target highlights in CASP14: Analysis of models by structure providers. Proteins Epub 2021/09/26. doi: 10.1002/prot.26247. PubMed PMID: 34561912.

Cogan DP, Zhang K, Li X, Li S, Pintilie GD, Roh SH, Craik CS, Chiu W, Khosla C. Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science. 2021;374(6568):729-34. Epub 2021/11/05. doi: 10.1126/science.abi8358. PubMed PMID: 34735239; PMCID: PMC8842837.

Pintilie G, Chiu W. Validation, analysis and annotation of cryo-EM structures. Acta Crystallogr D Struct Biol. 2021;77(Pt 9):1142-52. Epub 2021/09/03. doi: 10.1107/S2059798321006069. PubMed PMID: 34473085; PMCID: PMC8411978.

2020

Lawson, CL, Berman, HM, & Chiu, W (2020) Evolving data standards for cryo-EM structures. Struct Dyn 7(1):014701. PMCID6980868.

McClelland, LJ, Zhang, K, Mou, TC, Johnston, J, Yates-Hansen, C, Li, S, Thomas, CJ, Doukov, TI, Triest, S, Wohlkonig, A, Tall, GG, Steyaert, J, Chiu, W, & Sprang, SR (2020) Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Galphai1. Nat Commun 11(1):1077. PMCID7044438.

Guo, S, Vieweger, M, Zhang, K, Yin, H, Wang, H, Li, X, Li, S, Hu, S, Sparreboom, A, Evers, BM, Dong, Y, Chiu, W, & Guo, P (2020) Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy. Nat Commun 11(1):972. PMCID7033104.

Zhang, H, Pan, Y, Hu, L, Hudson, MA, Hofstetter, KS, Xu, Z, Rong, M, Wang, Z, Prasad, BVV, Lockless, SW, Chiu, W, & Zhou, M (2020) TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential. Nat Commun 11(1):547. PMCID6987127.

Zhang, K, Wang, S, Li, S, Zhu, Y, Pintilie, GD, Mou, TC, Schmid, MF, Huang, Z, & Chiu, W (2020) Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas complex revealed by cryo-EM. Proc Natl Acad Sci U S A 117(13):7176-7182. PMCID7132274.

Zhang, K, Pintilie, GD, Li, S, Schmid, MF, & Chiu, W (2020) Resolving individual atoms of protein complex by cryo-electron microscopy. Cell Res 10.1038/s41422-020-00432-2. PMCID7605492.

Partin, AC, Zhang, K, Jeong, BC, Herrell, E, Li, S, Chiu, W, & Nam, Y (2020) Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA. Mol Cell 78(3):411-422 e414. PMCID7214211.

Pintilie, G, Zhang, K, Su, Z, Li, S, Schmid, MF, & Chiu, W (2020) Measurement of atom resolvability in cryo-EM maps with Q-scores. Nat Methods 17(3):328-334. PMCID7446556.

Huang, CS, Yu, X, Fordstrom, P, Choi, K, Chung, BC, Roh, SH, Chiu, W, Zhou, M, Min, X, & Wang, Z (2020) Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition. Sci Adv 6(25):eabb1989. PMCID7304964.

Kappel, K, Zhang, K, Su, Z, Watkins, AM, Kladwang, W, Li, S, Pintilie, G, Topkar, VV, Rangan, R, Zheludev, IN, Yesselman, JD, Chiu, W, & Das, R (2020) Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures. Nat Methods 17(7):699-707. PMCID7386730.

Dahlberg, PD, Saurabh, S, Sartor, AM, Wang, J, Mitchell, PG, Chiu, W, Shapiro, L, & Moerner, WE (2020) Cryogenic single-molecule fluorescence annotations for electron tomography reveal in situ organization of key proteins in Caulobacter. Proc Natl Acad Sci U S A 117(25):13937-13944. PMCID7321984.

Oliver, SL, Xing, Y, Chen, DH, Roh, SH, Pintilie, GD, Bushnell, DA, Sommer, MH, Yang, E, Carfi, A, Chiu, W, & Arvin, AM (2020) A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation. Nat Commun 11(1):4141. PMCID7435202.

Roh, SH, Shekhar, M, Pintilie, G, Chipot, C, Wilkens, S, Singharoy, A, & Chiu, W (2020) Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of Vo complex. Sci Adv 6(41). PMCID7541076.

Muscarella, AM, Dai, W, Mitchell, PG, Zhang, W, Wang, H, Jia, L, Stossi, F, Mancini, MA, Chiu, W, & Zhang, XH (2020) Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells. NPJ Breast Cancer 6:42. PMCID7477119.

Kaelber, JT, Jiang, W, Weaver, SC, Auguste, AJ, & Chiu, W (2020) Arrangement of the Polymerase Complexes inside a Nine-Segmented dsRNA Virus. Structure 28(6):604-612 e603. PMCID7289189.

Campos, RK, Jin, J, Rafael, GH, Zhao, M, Liao, L, Simmons, G, Chu, S, Weaver, SC, Chiu, W, & Cui, Y (2020) Decontamination of SARS-CoV-2 and Other RNA Viruses from N95 Level Meltblown Polypropylene Fabric Using Heat under Different Humidities. ACS Nano 14(10):14017-14025. PMCID7526332.

Wu, GH, Mitchell, PG, Galaz-Montoya, JG, Hecksel, CW, Sontag, EM, Gangadharan, V, Marshman, J, Mankus, D, Bisher, ME, Lytton-Jean, AKR, Frydman, J, Czymmek, K, & Chiu, W (2020) Multi-scale 3D Cryo-Correlative Microscopy for Vitrified Cells. Structure 28(11):1231-1237 e1233. PMCID7642057.

Selzer, L, Su, Z, Pintilie, GD, Chiu, W, & Kirkegaard, K (2020) Full-length three-dimensional structure of the influenza A virus M1 protein and its organization into a matrix layer. PLoS Biol 18(9):e3000827. PMCID7549809.

Zhang, K, Li, S, Pintilie, G, Chmielewski, D, Schmid, MF, Simmons, G, Jin, J, & Chiu, W (2020) A 3.4-A cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles. QRB Discovery 1:E11. PMCID7430573.

Dahlberg, PD, Perez, D, Su, Z, Chiu, W, & Moerner, WE (2020) Cryogenic Correlative Single-Particle Photoluminescence Spectroscopy and Electron Tomography for Investigation of Nanomaterials. Angew Chem Int Ed Engl 10.1002/anie.202002856. PMCID7894979.

Li, Y, Huang, W, Li, Y, Chiu, W, & Cui, Y (2020) Opportunities for Cryogenic Electron Microscopy in Materials Science and Nanoscience. ACS Nano 14(8):9263-9276.

2019

Dosey, TL, Wang, Z, Fan, G, Zhang, Z, Serysheva, II, Chiu, W, & Wensel, TG (2019) Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Nat Struct Mol Biol 26(1):40-49. PMCID6458597.

Ge, Z, Su, Z, Simmons, CR, Li, J, Jiang, S, Li, W, Yang, Y, Liu, Y, Chiu, W, Fan, C, & Yan, H (2019) Redox Engineering of Cytochrome c using DNA Nanostructure-Based Charged Encapsulation and Spatial Control. ACS Appl Mater Interfaces 11(15):13874-13880. PMCID6325017.

Guo, M, Zhang, K, Zhu, Y, Pintilie, GD, Guan, X, Li, S, Schmid, MF, Ma, Z, Chiu, W, & Huang, Z (2019) Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry. Cell Res 29(4):305-312. PMCID6461802.

Michalska, K, Zhang, K, March, ZM, Hatzos-Skintges, C, Pintilie, G, Bigelow, L, Castellano, LM, Miles, LJ, Jackrel, ME, Chuang, E, Jedrzejczak, R, Shorter, J, Chiu, W, & Joachimiak, A (2019) Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events. Structure 27(3):449-463 e447. PMCID6403000.

Zhang, K, Zhang, H, Li, S, Pintilie, GD, Mou, TC, Gao, Y, Zhang, Q, van den Bedem, H, Schmid, MF, Au, SWN, & Chiu, W (2019) Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A oligomeric assemblies at near-atomic resolution. Proc Natl Acad Sci U S A 116(14):6800-6805. PMCID6452728.

Jun, H, Shepherd, TR, Zhang, K, Bricker, WP, Li, S, Chiu, W, & Bathe, M (2019) Automated Sequence Design of 3D Polyhedral Wireframe DNA Origami with Honeycomb Edges. ACS Nano 13(2):2083-2093. PMCID6679942.

Gestaut, D, Roh, SH, Ma, B, Pintilie, G, Joachimiak, LA, Leitner, A, Walzthoeni, T, Aebersold, R, Chiu, W, & Frydman, J (2019) The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis. Cell 177(3):751-765 e715. PMCID6629582.

Li, Y, Zhou, W, Li, Y, Huang, W, Zhang, Z, Chen, G, Wang, H, Wu, G-H, Rolston, N, Vila, R, Chiu, w, & Cui, Y (2019) Unravelling Degradation Mechanisms and Atomic Structure of Organic-Inorganic Halide Perovskites by Cryo-EM. Joule 3(11):2854-2866.

Li, S, Su, Z, Lehmann, J, Stamatopoulou, V, Giarimoglou, N, Henderson, FE, Fan, L, Pintilie, GD, Zhang, K, Chen, M, Ludtke, SJ, Wang, YX, Stathopoulos, C, Chiu, W, & Zhang, J (2019) Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions. Nat Struct Mol Biol 26(12):1094-1105. PMCID6899168.

Pintilie, G, Chen, DH, Tran, BN, Jakana, J, Wu, J, Hew, CL, & Chiu, W (2019) Segmentation and Comparative Modeling in an 8.6-Å Cryo-EM Map of the Singapore Grouper Iridovirus. Structure 27(10):1561-1569 e1564. PMCID6853598.

Zhang, K, Li, S, Kappel, K, Pintilie, G, Su, Z, Mou, TC, Schmid, MF, Das, R, & Chiu, W (2019) Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution. Nat Commun 10(1):5511. PMCID6890682.

2018

Zhang, K., S. C. Keane, Z. Su, R. N. Irobalieva, M. Chen, V. Van, C. A. Sciandra, J. Marchant, X. Heng, M. F. Schmid, D. A. Case, S. J. Ludtke, M. F. Summers and W. Chiu (2018). Structure of the 30 kDa HIV-1 RNA Dimerization Signal by a Hybrid Cryo-EM, NMR, and Molecular Dynamics Approach. Structure 26(3): 490-498 e493. PMCID5842133.

Sun, SY, Kaelber, JT, Chen, M, Dong, X, Nematbakhsh, Y, Shi, J, Dougherty, M, Lim, CT, Schmid, MF, Chiu, W, & He, CY (2018) Flagellum couples cell shape to motility in Trypanosoma brucei. Proc Natl Acad Sci U S A 115(26):E5916-E5925. PMCID6042131.

Su, Z., C. Wu, L. Shi, P. Luthra, G. D. Pintilie, B. Johnson, J. R. Porter, P. Ge, M. Chen, G. Liu, T. E. Frederick, J. M. Binning, G. R. Bowman, Z. H. Zhou, C. F. Basler, M. L. Gross, D. W. Leung, W. Chiu and G. K. Amarasinghe (2018). Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly. Cell 172(5): 966-978 e912. PMCID5973842.

Qi, X, Zhang, F, Su, Z, Jiang, S, Han, D, Ding, B, Liu, Y, Chiu, W, Yin, P, & Yan, H (2018) Programming molecular topologies from single-stranded nucleic acids. Nat Commun 9(1):4579. PMCID6214983.

Roh, S. H., N. J. Stam, C. F. Hryc, S. Couoh-Cardel, G. Pintilie, W. Chiu and S. Wilkens (2018). The 3.5-Å CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase Vo Proton Channel. Mol Cell 69(6): 993-1004 e1003. PMCID5893162.

Jin, J., J. G. Galaz-Montoya, M. B. Sherman, S. Y. Sun, C. S. Goldsmith, E. T. O'Toole, L. Ackerman, L. A. Carlson, S. C. Weaver, W. Chiu and G. Simmons (2018). Neutralizing Antibodies Inhibit Chikungunya Virus Budding at the Plasma Membrane. Cell Host Microbe 24(3): 417-428 e415. PMCID6137268.

Erasmus, J. H., R. L. Seymour, J. T. Kaelber, D. Y. Kim, G. Leal, M. B. Sherman, I. Frolov, W. Chiu, S. C. Weaver and F. Nasar (2018). Novel Insect-Specific Eilat Virus-Based Chimeric Vaccine Candidates Provide Durable, Mono- and Multivalent, Single-Dose Protection against Lethal Alphavirus Challenge. J Virol 92(4). PMC5790933.

Duyvesteyn, H. M. E., A. Kotecha, H. M. Ginn, C. W. Hecksel, E. V. Beale, F. de Haas, G. Evans, P. Zhang, W. Chiu and D. I. Stuart (2018). Machining protein microcrystals for structure determination by electron diffraction. Proc Natl Acad Sci U S A 115(38): 9569-9573. PMCID6156647.

Du, D., Z. Wang, W. Chiu and B. F. Luisi (2018). Purification of AcrAB-TolC Multidrug Efflux Pump for Cryo-EM Analysis. Methods Mol Biol 1700: 71-81.

Dai, W., M. Chen, C. Myers, S. J. Ludtke, B. M. Pettitt, J. A. King, M. F. Schmid and W. Chiu (2018). Visualizing Individual RuBisCO and Its Assembly into Carboxysomes in Marine Cyanobacteria by Cryo-Electron Tomography. J Mol Biol 430(21): 4156-4167. PMCID6252266.

Pintilie, G & Chiu, W (2018) Assessment of structural features in Cryo-EM density maps using SSE and side chain Z-scores. J Struct Biol 204(3):564-571. PMCID6525962.

Kryshtafovych, A, Monastyrskyy, B, Adams, PD, Lawson, CL, & Chiu, W (2018) Distribution of evaluation scores for the models submitted to the second cryo-EM model challenge. Data Brief 20:1629-1638. PMCID6157618.

Kryshtafovych, A, Adams, PD, Lawson, CL, & Chiu, W (2018) Evaluation system and web infrastructure for the second cryo-EM model challenge. J Struct Biol 204(1):96-108. PMCID6205695.

2017

Erasmus, JH, Auguste, AJ, Kaelber, JT, Luo, H, Rossi, SL, Fenton, K, Leal, G, Kim, DY, Chiu, W, Wang, T, Frolov, I, Nasar, F, & Weaver, SC (2017) A chikungunya fever vaccine utilizing an insect-specific virus platform. Nat Med 23(2):192-199. PMCID5296253.

Murata, K, Zhang, Q, Gerardo Galaz-Montoya, J, Fu, C, Coleman, ML, Osburne, MS, Schmid, MF, Sullivan, MB, Chisholm, SW, & Chiu, W (2017) Visualizing Adsorption of Cyanophage P-SSP7 onto Marine Prochlorococcus. Sci Rep 7:44176. PMCID5345008.

Luengo, I, Darrow, MC, Spink, MC, Sun, Y, Dai, W, He, CY, Chiu, W, Pridmore, T, Ashton, AW, Duke, EMH, Basham, M, & French, AP (2017) SuRVoS: Super-Region Volume Segmentation workbench. J Struct Biol 198(1):43-53. PMCID5405849.

Kaelber, JT, Hryc, CF, & Chiu, W (2017) Electron Cryomicroscopy of Viruses at Near-Atomic Resolutions. Annu Rev Virol 10.1146/annurev-virology-101416-041921.

Hryc, CF, Chen, DH, Afonine, PV, Jakana, J, Wang, Z, Haase-Pettingell, C, Jiang, W, Adams, PD, King, JA, Schmid, MF, & Chiu, W (2017) Accurate model annotation of a near-atomic resolution cryo-EM map. Proc Natl Acad Sci U S A 114:3103-3108. PMCID5373346.

Wang, Z, Fan, G, Hryc, CF, Blaza, JN, Serysheva, II, Schmid, MF, Chiu, W, Luisi, BF, & Du, D (2017) An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Elife 6. PMCID5404916

Roh, SH, Hryc, CF, Jeong, HH, Fei, X, Jakana, J, Lorimer, GH, & Chiu, W (2017) Subunit conformational variation within individual GroEL oligomers resolved by Cryo-EM. Proc Natl Acad Sci U S A 114(31):8259-8264. PMCID5547627.

Yi, P, Wang, Z, Feng, Q, Chou, CK, Pintilie, GD, Shen, H, Foulds, CE, Fan, G, Serysheva, I, Ludtke, SJ, Schmid, MF, Hung, MC, Chiu, W, & O'Malley, BW (2017) Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell 67(5):733-743 e734. PMCID5657569.

Chiu, W & Downing, KH (2017) Editorial overview: Cryo Electron Microscopy: Exciting advances in CryoEM Herald a new era in structural biology. Curr Opin Struct Biol 46:iv-viii. PMCID5683930.

Chen, M, Dai, W, Sun, SY, Jonasch, D, He, CY, Schmid, MF, Chiu, W, & Ludtke, SJ (2017) Convolutional neural networks for automated annotation of cellular cryo-electron tomograms. Nat Methods 14(10):983-985. PMCID5623144.

Lan, X, Su, Z, Zhou, Y, Meyer, T, Ke, Y, Wang, Q, Chiu, W, Liu, N, Zou, S, Yan, H, & Liu, Y (2017) Programmable Supra-Assembly of a DNA Surface Adapter for Tunable Chiral Directional Self-Assembly of Gold Nanorods. Angew Chem Int Ed Engl 56(46):14632-14636.

Wang, Q, Irobalieva, RN, Chiu, W, Schmid, MF, Fogg, JM, Zechiedrich, L, & Pettitt, BM (2017) Influence of DNA sequence on the structure of minicircles under torsional stress. Nucleic Acids Res 45(13):7633-7642. PMCID5737869.

2016

Lawson, CL, Patwardhan, A, Baker, ML, Hryc, C, Garcia, ES, Hudson, BP, Lagerstedt, I, Ludtke, SJ, Pintilie, G, Sala, R, Westbrook, JD, Berman, HM, Kleywegt, GJ, & Chiu, W (2016) EMDataBank unified data resource for 3DEM. Nucleic acids research 44(D1):D396-403. PMCID4702818.

Galaz-Montoya, JG, Hecksel, CW, Baldwin, PR, Wang, E, Weaver, SC, Schmid, MF, Ludtke, SJ, & Chiu, W (2016) Alignment algorithms and per-particle CTF correction for single particle cryo-electron tomography. Journal of structural biology 194(3):383-394. PMCID4846534.

Pintilie, G, Chen, DH, Haase-Pettingell, CA, King, JA, & Chiu, W (2016) Resolution and Probabilistic Models of Components in CryoEM Maps of Mature P22 Bacteriophage. Biophysical journal 110(4):827-839. PMCID4775875.

Roh, SH, Kasembeli, M, Galaz-Montoya, JG, Trnka, M, Lau, WC, Burlingame, A, Chiu, W, & Tweardy, DJ (2016) Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO. The Journal of biological chemistry 291(9):4732-4741. PMCID4813495.

Marabini, R, Ludtke, SJ, Murray, SC, Chiu, W, de la Rosa-Trevin, JM, Patwardhan, A, Heymann, JB, & Carazo, JM (2016) The Electron Microscopy eXchange (EMX) initiative. Journal of structural biology 194(2):156-163.

Hecksel, CW, Darrow, MC, Dai, W, Galaz-Montoya, JG, Chin, JA, Mitchell, PG, Chen, S, Jakana, J, Schmid, MF, & Chiu, W (2016) Quantifying Variability of Manual Annotation in Cryo-Electron Tomograms. Microsc Microanal 22(3):487-496. PMCID5111626.

Veneziano, R, Ratanalert, S, Zhang, K, Zhang, F, Yan, H, Chiu, W, & Bathe, M (2016) Designer nanoscale DNA assemblies programmed from the top down. Science 352(6293):1534. PMCID5111087.

Li, H, Zhang, K, Pi, F, Guo, S, Shlyakhtenko, L, Chiu, W, Shu, D, & Guo, P (2016) Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting. Adv Mater 28(34):7501-7507. PMCID5059845.

DiMaio, F & Chiu, W (2016) Tools for Model Building and Optimization into Near-Atomic Resolution Electron Cryo-Microscopy Density Maps. Methods Enzymol 579:255-276. PMCID5103630

Roh, SH, Kasembeli, MM, Galaz-Montoya, JG, Chiu, W, & Tweardy, DJ (2016) Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions. Biophys J 110(11):2377-2385. PMCID4906440.

Darrow, MC, Zhang, Y, Cinquin, BP, Smith, EA, Boudreau, R, Rochat, RH, Schmid, MF, Xia, Y, Larabell, CA, & Chiu, W (2016) Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography. J Cell Sci 129(18):3511-3517. PMCID5047677.

Zhao, X, Chen, XQ, Han, E, Hu, Y, Paik, P, Ding, Z, Overman, J, Lau, AL, Shahmoradian, SH, Chiu, W, Thompson, LM, Wu, C, & Mobley, WC (2016) TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proc Natl Acad Sci U S A 113(38):E5655-5664. PMCID5035849.

Shen, K, Calamini, B, Fauerbach, JA, Ma, B, Shahmoradian, SH, Serrano Lachapel, IL, Chiu, W, Lo, DC, & Frydman, J (2016) Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract. Elife 5. PMCID5135392.

Khisamutdinov, EF, Jasinski, DL, Li, H, Zhang, K, Chiu, W, & Guo, P (2016) Fabrication of RNA 3D Nanoprisms for Loading and Protection of Small RNAs and Model Drugs. Adv Mater 28(45):10079-10087. PMCID5224701.