Chiu Lab Preprints
2023
Mengyuan Xu, Torben Neelands, Alexander S. Powers, Yan Liu, Steven D. Miller, Grigore Pintilie, J. Du Bois, Ron O. Dror, Wah Chiu, Merritt Maduke (29 November 2023) CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism bioRxiv | Paper | Link
Rahel A. Woldeyes, Masataka Nishiga, Alison S. Vander Roest, Leeya Engel, Prerna Giri, Gabrielle C. Montenegro, Andrew C. Wu, Alexandr R. Dunn, James A. Spudich, Daniel Bernstein, Michael F. Schmid, Joseph C. Wu, Wah Chiu (26 October 2023) Cryo-electron tomography reveals the structural diversity of cardiac proteins in their cellular context bioRxiv | Paper | Link
David Chmielewski, Eric A. Wilson, Grigore Pintilie, Peng Zhao, Muyuan Chen, Michael F. Schmid, Graham Simmons, Lance Wells, Jing Jin, Abhishek Singharoy, Wah Chiu (15 February 2023) Integrated anaylses reveal a hinge glycan regulates coronavirus spike tilting and virus infectivity. Res Sq | Paper | Link
2022
Yaw Bia Tan, David Chmielewski, Michelle Cheok Yien Law, Kuo Zhang, Yu He, Muyuan Chen, Jing Jin, Dahai Luo, Wah Chiu (2022) Molecular Architecture of the Chikungunya Virus Replication Complex. bioRxiv. | Paper | Link
Gong-Her Wu, Charlene Smith-Geater, Jesús G Galaz-Montoya, Yingli Gu, Sanket R Gupte, Ranen Aviner, Patrick G Mitchell, Joy Hsu, Ricardo Miramontes, Keona Q Wang, Nicolette R Geller, Cristina Danita, Lydia-Marie Joubert, Michael F Schmid, Serena Yeung, Judith Frydman, William Mobley, Chengbiao Wu, Leslie M Thompson, Wah Chiu (2022) CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons. bioRxiv. | Paper | Link
Daniel Gestaut, Yanyan Zhao, Junsun Park, Boxue Ma, Alexander Leitner, Miranda Collier, Grigore Pintilie, Soung-Hun Roh, Wah Chiu, Judith Frydman (2022) Structural visualization of the tubulin folding pathway directed by eukaryotic chaperonin TRiC. bioRxiv. | Paper | Link
Li-av Segev-Zarko, Peter D Dahlberg, Stella Y Sun, Daniël M Pelt, James A Sethian, Wah Chiu, John C Boothroyd (2022) Ionophore-stimulation promotes re-organization of the invasion machinery of Toxoplasma gondii. bioRxiv. | Paper | Link
2021
Stella Y Sun, Li-av Segev-Zarko, Muyuan Chen, Grigore D Pintilie, Michael F Schmid, Steven J Ludtke, John C Boothroyd, Wah Chiu (2021) Cryo-ET reveals two major tubulin-based cytoskeleton structures in Toxoplasma gondii. bioRxiv. | Paper | Link
David Chmielewski, Jason Kaelber, Jing Jin, Scott C Weaver, Albert J Auguste, Wah Chiu (2021) Near-atomic resolution Cryo-EM structure of Mayaro virus identifies key structural determinants of alphavirus particle formation. bioRxiv. | Paper | Link
Kaiming Zhang, Shanshan Li, Kan-Yen Hsieh, Shih-Chieh Su, Grigore D Pintilie, Wah Chiu, Chung-I Chang (2021) Molecular basis for the ATPase-powered substrate translocation by the Lon AAA+ protease. bioRxiv. | Paper | Link